Editor’s Note — CNN Travel updates this article periodically. It was last updated in its entirety on March 23.
The health risks are obvious if you’re not fully vaccinated. Venues and events of interest to travelers might impose restrictions. Nations might change their rules with little notice after you’ve made plans or you’re already on your trip.
Latest news
Russia has invaded Ukraine, and the State Department has “do not travel” advisories for both.
What to find out before you go
What follows is a curated list of countries and territories, alphabetically organized by continent or region, where US passport holders are allowed entry for leisure travel.
Click the links by each destination for crucial information on:
• Whether you’re required to be fully vaccinated to enter. Some countries on this list accept only fully vaccinated Americans.
• Possible exemptions from various rules for the fully vaccinated, people recovered from a recent case of Covid-19 or children.
• Presenting negative results from Covid-19 tests to enter, including time limits to take the test, types of tests allowed and additional tests upon arrival.
• Possible quarantines and durations as well as health screenings upon arrival.
• Health insurance requirements, curfews and lockdowns.
• Different rules if you’re arriving from a third country vs. the United States as well as rules for land and sea entry, which might differ from air arrivals.
• What safety rating the CDC gives the destination
The links to various government and tourism sites next to each country will help you gather the most current information for your journey.
Africa (sub-Saharan)

Dakar, Senegal, is becoming quite the surfing spot.
CNN
Africa offers a huge variety of travel options — outdoor adventures in just about any climate and a wide array of cultures and urban experiences. There are 54 countries on the continent — each with its own response to the pandemic. As of late March, many of the countries the CDC rated safest for travel regarding Covid-19 are in Africa.
The nations of northern Africa can be found in the Middle East and North Africa grouping further below.
Asia

Houseboat rides in the backwaters of Kerala, India, are popular.
CHRISTOPHE ARCHAMBAULT/AFP/AFP/Getty Images
Generally, Asian destinations have been much slower to reopen to international tourism than the rest of world. Tourism giants such as Japan and China are still closed to US leisure travelers. However, more and more places have opened their doors to Americans on vacation, with the Philippines being one of the more recent ones. Malaysia is set to open April 1.
Australia / Pacific Islands

Phillip Island is a popular getaway near Melbourne.
National Parks Australia
Europe

A train ride from Porto along the Douro River Valley provides breathtaking views in Portugal.
Antonio Sacchetti/Turismo de Portugal
In late March, many destinations in Europe were still under a “avoid” advisory from the CDC.
US tourists are still allowed to visit most destinations there, although full vaccinations are required in many of the countries.
Middle East / North Africa
Rich in culture and history, destinations in the Middle East and North Africa are also trying to deal with a modern pandemic just like the rest of the world.
North America / Caribbean

Bonaire is a haven for scuba divers and has fascinating sea life.
Courtesy Tourism Corporation Bonaire
North America and the Caribbean now give US leisure travelers plenty of travel options with a relatively short plane ride. Be sure to check disembarking rules if you take a Caribbean cruise.
South America

A view of Copacabana, a Bolivian tourist town on Lake Titicaca.
Aizar Raldes/AFP/Getty Images
South America’s pandemic journey has mirrored the rest of the world in terms of mixed responses. Brazil has been wide open for the long haul while Argentina just recently opened to US travelers.
Omitted countries
This is a curated list and not a complete catalog of every single destination open to visitors from the United States.
CNN Travel has omitted certain countries if they: had very limited numbers of American travelers before the pandemic; are very isolated or have little to no tourism infrastructure; have ongoing or recent armed conflicts, terrorism or rampant crime and unrest; have a current credible threat of warfare; have antagonistic relations with the US government; or have entry requirements so extensive and complicated that they put the country out of reach of almost all US citizens.